CLGI, Collagenase inhibitor, EPA, EPO, FLJ90373, HCI, Metalloproteinase inhibitor 1, TIMP, TIMP 1, TIMP1.
TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that functions by forms one-to-one complexes with target metallproteinases, such as collagenases, and irreversible inactivates them by binding to their catalytic zinc cofactor. TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16. It also functions as a growth factor that regulates cell differenation, migration, and cell death. TIMP1 activates cellular signaling cascades via CD63 and ITGB1.
Proben:
FFPE tissue
Target-Kategorie:
Human TIMP1
IHC0141H
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