75 kDa bromodomain protein, BP75, BRD 7, BRD7, BRD7_HUMAN, Bromodomain containing 7, bromodomain containing protein 7, Bromodomain-containing protein 7, CELTIX 1, CELTIX1, NAG4, Protein CELTIX-1.
BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
Proben:
FFPE tissue
Target-Kategorie:
Mouse BRD7
IHC0180M
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