HLA-6.2, HLA class I histocompatibility antigen E alpha chain, DKFZp686P19218, EA1.2, EA2.1, HLA 6.2, HLA class I histocompatibility antigen alpha chain E, HLA class I histocompatibility antigen E alpha chain precursor, HLA-6.2, HLA6.2, HLAE, Lymphocyte antigen, Major histocompatibility complex class I E, MHC, MHC class I antigen E, MHC HLA E alpha 1, MHC HLA E alpha 2.1, HLA-E, QA1.
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
Proben:
FFPE tissue
Target-Kategorie:
Human HLA E
IHC0205H
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