Human CD80 Ready-To-Use IHC Kit

Produktübersicht

• Artikelname: Human CD80 Ready-To-Use IHC Kit
• Artikelnummer: BSS-IHC0231H
• Hersteller Artikelnummer: IHC0231H
• Alternativnummer: BSS-IHC0231H-50
• Hersteller: Bioss
• Kategorie: Kits/Assays
• Spezies Reaktivität: Human
• Alternative Synonym: B7, B7-1, B71, Cd28l, Cd80, Ly-53, Ly53, MIC17, TSA1, Activation B7-1 antigen, B lymphocyte activation antigen B7, B7-1 antigen, BB1, CD28 antigen ligand 1, CD28LG, CD28LG1, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 antigen, CD80 molecule, CD80_HUMAN, Costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80.

Produktbeschreibung

CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

Produkteigenschaften

• Proben: FFPE tissue
• Target-Kategorie: Human CD80

Bilder

IHC0231H