Human APAF1 Ready-To-Use IHC Kit

Produktübersicht

• Artikelname: Human APAF1 Ready-To-Use IHC Kit
• Artikelnummer: BSS-IHC0336H
• Hersteller Artikelnummer: IHC0336H
• Alternativnummer: BSS-IHC0336H-50
• Hersteller: Bioss
• Kategorie: Kits/Assays
• Spezies Reaktivität: Human
• Alternative Synonym: 6230400I06Rik, APAF-1, Apaf1l, fog, mKIAA0413, APAF 1, APAF1, CED4, DKFZp781B1145, KIAA0413.

Produktbeschreibung

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Produkteigenschaften

• Proben: FFPE tissue
• Target-Kategorie: Human APAF1

Bilder

IHC0336H