Human SCF Ready-To-Use IHC Kit

Produktübersicht

• Artikelname: Human SCF Ready-To-Use IHC Kit
• Artikelnummer: BSS-IHC0338H
• Hersteller Artikelnummer: IHC0338H
• Alternativnummer: BSS-IHC0338H-50
• Hersteller: Bioss
• Kategorie: Kits/Assays
• Spezies Reaktivität: Human
• Alternative Synonym: DCUA, DFNA69, FPH2, FPHH, KL-1, SCF, Stem Cell Factor, C kit ligand, Ckit ligand, DKFZp686F2250, KIT ligand, Kitl, KITLG, KL 1, KL1, Mast cell growth factor, MGF, SF, SHEP7, Steel factor, Stem cell factor precursor, SCF_HUMAN

Produktbeschreibung

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

Produkteigenschaften

• Proben: FFPE tissue
• Target-Kategorie: Human SCF

Bilder

IHC0338H