A I, Al, ARG 1, arg1, ARGI1_HUMAN, Arginase 1, Arginase liver, Arginase type I, Arginase, liver, Arginase-1, Arginase1, Liver type arginase, Liver-type arginase, Type I arginase, AI256583, Arg-1, ARG1, PGIFa
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removalof toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
Proben:
FFPE tissue
Target-Kategorie:
Mouse Arginase 1
IHC0435M
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