C230057C06Rik, Estm14, Grg-1, GRG1, Tle4l, TLE 1, E(Sp1) homolog, Enhancer of split groucho 1, Enhancer of split groucho like protein 1, Enhancer of split groucho-like protein 1, ESG, ESG1, GRG1, TLE1, TLE1_HUMAN, Transducin like enhancer of split 1 (E(sp1) homolog Drosophila), Transducin like enhancer of split 1, Transducin like enhancer of split 1 homolog of Drosophila E(sp1), Transducin like enhancer protein 1, Transducin-like enhancer protein 1a
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Proben:
FFPE tissue
Target-Kategorie:
Human TLE1
IHC0585H
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