BPA-2, Bpag, ERED, LAD-1, 180 kDa bullous pemphigoid antigen 2, Alpha 1 type XVII collagen, BA16H23.2, BP 180, BP180, BPA 2, BPAG 2, BPAG2, Bullous pemphigoid antigen 2, COL17A1, Collagen 17, Collagen alpha 1 XVII chain, Collagen alpha 1(XVII) chain, Collagen alpha1 XVII chain, Collagen type XVII alpha 1, Collagen XVII alpha 1 polypeptide, CollagenXVII, Epidermolysis bullosa junctional localisata variant, FLJ60881, KIAA0204, LAD 1, LAD1a
COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.
Proben:
FFPE tissue
Target-Kategorie:
Human Collagen XVII
IHC0688H
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