Synthetic peptide, corresponding to amino acids 60-110 of Human LYVE-1.
Konjugation:
Unconjugated
Alternative Synonym:
Cell surface retention sequence-binding protein 1, CRSBP 1, CRSBP-1, CRSBP1, extracellular link domain containing 1, extracellular link domain-containing 1, Extracellular link domain-containing protein 1, HAR, hyaluronic acid receptor, Lymphatic endothelium specific hyaluronan receptor, lymphatic vessel endothelial hyaluronan receptor 1, Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE 1, LYVE-1, LYVE1, LYVE1, XLKD1,
Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IF: 1:100~1:500
Anwendungsbeschreibung:
LYVE-1 polyclonal antibody detects endogenous levels of LYVE-1 protein.
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