Synthetic peptide, corresponding to amino acids 331-380 of Human SSB.
Konjugation:
Unconjugated
Alternative Synonym:
Autoantigen La, La, La autoantigen, La autoantigen homolog, La protein, La ribonucleoprotein, La ribonucleoprotein domain family member 3, LA, LARP3, Lupus La antigen, Lupus La protein, Lupus La protein homolog, MGC118101, MGC93380, mRNA for autoantigen, OTTMUSP00000014043, RP23 273G23.1, Sjoegren syndrome type B antigen, Sjoegren syndrome type B antigen, Sjogren syndrome antigen B (autoantigen La), Sjogren syndrome antigen B, SS B, SS-B, SS-B/La protein, SSB,
Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 110% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:1000~1:2000
Anwendungsbeschreibung:
SSB(T362) polyclonal antibody detects endogenous levels of SSB protein.
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