Sharing 41% sequence identity with human Interferon gamma (hIFN--gamma), mouse IFN gamma (mIFN--gamma)is a macrophage-activating factor.The active form of IFN--gamma is an antiparallel dimer that sets off IFN--gamma/JAK/STAT pathway. IFN--gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity.While IFN--gamma-induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN--gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in avariety of cancers.Recombinant mouse IFN gamma (rmIFN-gamma) produced in E.coli is a non-glycosylated polypeptide chain of 134 amino acids. A fully biologically active molecule, rmIFN--gamma has a molecular mass of 15 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
Molekulargewicht:
15 kDa, observed by reducing SDS-PAGE.
Quelle:
Escherichia coli.
Reinheit:
> 95% as analyzed by reducing SDS-PAGE.
Formulierung:
Sterile Filtered White lyophilized (freeze-dried) powder.
