Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with gamma chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
Molekulargewicht:
40-45 kDa, observed by reducing SDS-PAGE.
Quelle:
HEK 293
Reinheit:
> 95% as analyzed by SDS-PAGE and HPLC.
Formulierung:
Sterile Filtered White lyophilized (freeze-dried) powder.
