Synthetic peptide, corresponding to amino acids 61-110 of Human Gastrin.
Konjugation:
Unconjugated
Alternative Synonym:
Gastrin, Gastrin-71, Gastrin 71, Gastrin71, Gastrin component I, Gastrin-52, Gastrin 52, Gastrin52, Big gastrin, Gastrin component II, Gastrin-34, Gastrin 34, Gastrin34, Gastrin, Gastrin component III, Gastrin-17, Gastrin-14, Gastrin-6, Gastrin 17, Gastrin 14, Gastrin 6, Gastrin17, Gastrin14, Gastrin6, GAST, GAS
Gastrin, which is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, is a hormone whose main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Gastrin also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger- Ellison syndrome. Gastrin maps to human chromosome 17q-21. Gastrin- Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones, in addition to acting as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems and, interestingly, is induced by retinoic acid.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
IHC: 1:50~1:200 IF: 1:50~1:200
Anwendungsbeschreibung:
Gastrin (M90) polyclonal antibody detects endogenous levels of Gastrin protein.
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