The matrix metalloproteinases (MMP) are a family ofpeptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibroPVRL1, laminin and proteoglycan. Transcriptionof MMP genes is differentially activated by phorbol ester,lipopolysaccharide (LPS) or staphylococcal enterotoxin B(SEB). MMP catalysis requires both calcium and zinc.MMP-13 (also designated collagenase-3) is produced bybreast carcinomas and degrades collagen types I, II andIII. MMP-13 has wide substrate specificity, and its physiologic expression is limited to situations in which rapidand effective remodeling of collagenous ECM takesplace, such as fetal bone development and adult bone remodeling
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Anwendungsbeschreibung:
MMP-13 (L22) polyclonal antibody detects endogenouslevels of ~55 kDa latent or the ~40 kDa active forms ofMMP-13 protein.
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