PKD1/2/3 (I740) polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: PKD1/2/3 (I740) polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS1685
• Hersteller Artikelnummer: BS1685
• Alternativnummer: BWT-BS1685-50UL,BWT-BS1685-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids 708-763 of Human PKD1.
• Konjugation: Unconjugated
• Alternative Synonym: Serine/threonine-protein kinase D1, Protein kinase C mu type, Protein kinase D, nPKC-D1, nPKC-mu, PRKD1, PKD, PKD1, PRKCM, PKCmu, PKC mu, PKC-mu, Serine/threonine-protein kinase D2, nPKC-D2, PRKD2, PKD2, HSPC187, PKC mu, PKCmu, Serine/threonine-protein kinase D3, Protein kinase C nu type, Protein kinase EPK2, nPKC-nu, PRKD3, EPK2, PRKCN, PKD3, PKCnu, PKC nu, PKC-nu, PKC nu, PKCnu, PKC-nu

Produktbeschreibung

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (alpha, betaI, betaII and gamma) and novel (n) PKC isoforms (delta, epsilon, zeta, eta and theta). Patterns of expression for each PKC isoform differs among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and epsilon are independent of Ca 2+. On the other hand, nPKC delta and epsilon, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.

Produkteigenschaften

• Molekulargewicht: ~ 90 to 140 kDa
• UniProt: Q15139
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Anwendungsbeschreibung

• Application Verdünnung: WB: 1:500~1:1000
• Anwendungsbeschreibung: PKD1/2/3 (I740) polyclonal antibody detects endogenous levels of PKD1/2/3 protein.