Synthetic peptide, corresponding to amino acids 102-150 of Human ERAB.
Konjugation:
Unconjugated
Alternative Synonym:
3-hydroxyacyl-CoA dehydrogenase type-2, 17-beta-hydroxysteroid dehydrogenase 10, 17-beta-HSD 10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, HSD17B10, ERAB, HADH2, MRPP2, SCHAD, XH98G2
beta-Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimers disease. beta-Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of beta-Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum-associated beta-Amyloid-binding protein. ERAB is characterized as a NAD+-dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimers disease. Cells overexpressing ERAB in vitro have been shown to be more sensitive to beta-Amyloid-induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that beta-Amyloid induced cell death is mediated by ERAB.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:200
Anwendungsbeschreibung:
ERAB (E135) polyclonal antibody detects endogenous levels of ERAB protein.
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