Synthetic peptide, corresponding to amino acids 1246-1310 of Human ErbB-4.
Konjugation:
Unconjugated
Alternative Synonym:
4ICD, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, E4ICD, EC 2.7.10.1, ErbB4, ERBB4 intracellular domain, ERBB4, HER 4, HER4, Mer4, MGC138404, Oncogene ERBB4, P180erbB4, Proto-oncogene-like protein c-ErbB-4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4, s80HER4, Tyrosine kinase type cell surface receptor HER4, Tyrosine kinase-type cell surface receptor HER4, v erb a avi
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
IHC: 1:50~1:200 IF: 1:50~1:200
Anwendungsbeschreibung:
ErbB-4 (E1280) polyclonal antibody detects endogenous levels of ErbB-4 protein.
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