Synthetic peptide, corresponding to amino acids 136-180 of Human HMGB2.
Konjugation:
Unconjugated
Alternative Synonym:
High mobility group (nonhistone chromosomal) protein 2, high mobility group box 2, High mobility group protein 2, High mobility group protein B2, high-mobility group (nonhistone chromosomal) protein 2, HMG 2, HMG B2, HMG-B2, HMG-2, HMG2, HMGB-2,
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the N kappaB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
IHC: 1:50~1:200
Anwendungsbeschreibung:
HMGB2 (K165) polyclonal antibody detects endogenous levels of HMGB2 protein.
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