ERK1/2 (R189) polyclonal antibody, Unconjugated, Rabbit
Artikelnummer:
BWT-BS1968
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| Artikelname: | ERK1/2 (R189) polyclonal antibody, Unconjugated, Rabbit |
| Artikelnummer: | BWT-BS1968 |
| Hersteller Artikelnummer: | BS1968 |
| Alternativnummer: | BWT-BS1968-50UL,BWT-BS1968-100UL |
| Hersteller: | Bioworld Technology |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | IF, IHC, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide, corresponding to amino acids 150-200 of Human ERK1. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, ERK1, PRKM3, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, MAPK1, ERK2, PRKM1, PRKM2 |
| The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr- Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos-phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6. |
| Molekulargewicht: | ~ 42, 44 kDa |
| UniProt: | P27361 |
| Reinheit: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Formulierung: | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Application Verdünnung: | WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200 |
| Anwendungsbeschreibung: | ERK1/2 (R189) polyclonal antibody detects endogenous levels of ERK1/2 protein. |
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