C/EBP family members include C/EBP alpha, C/EBP beta, C/EBP gamma, C/EBP delta, C/EBP epsilon and C/EBP zeta, all of which are capable of forming homodimers or heterodimers with each other. C/EBP zeta, also known as CBF2, NOC1, CHOP10 (C/EBP homologous protein 10), GADD153 (growth arrest and DNA damage-inducible gene 153) or HSPCBF, is a ubiquitously expressed 1,054 amino acid protein that localizes to the nucleus and regulates transcription. More specifically, C/EBP zeta is believed to play a role regulating the expression of CRP (C-reactive protein). Unlike most C/EBP dimers, C/EBP zeta-containing dimers do not bind the classical C/EBP-binding consensus sequence. Rather, C/EBP zeta-containing dimers must associate with RBP-Jkappa (another transcription factor) in order to accomplish binding to the C/EBP site.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
