Synthetic peptide, corresponding to amino acids 150-198 of Human Syndecan-4.
Konjugation:
Unconjugated
Alternative Synonym:
SDC4, AMPHIGLYCAN, MGC22217, SYND4
Syndecans are type I integral membrane proteoglycans that contain both chondroitin sulfate and heparan sulfate groups. Syndecans are involved in cell-extracellular matrix adhesion and growth factor binding. Syndecan-1 (SYND1, also called CD138) is an 85-92 kDa extracellular matrix receptor, which binds to Collagens, Fibronectin and Thrombospondin. Syndecan-1 and Syndecan-3 (also designated N-Syndecan) interact with MK (midkine), a growth/differentiation factor invloved in embryogenesis of the central nervous system. Syndecan-2 (also designated Fibroglycan) is highly expressed at areas of high morphogenetic activity, such as epithelial-mesenchymal interfaces and the prechondrogenic and preosteogenic mesenchymal condensations. Syndecan-4 (also designated Amphiglycan or Ryudocan) functions cooperatively with integrins in the processes of cell spreading, focal adhesion assembly and actin stress fiber assembly.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Anwendungsbeschreibung:
Syndecan-4 (K175) polyclonal antibody detects endogenous levels of Syndecan-4 protein.
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