Cofilin (M1) polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: Cofilin (M1) polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS3579
• Hersteller Artikelnummer: BS3579
• Alternativnummer: BWT-BS3579-50UL,BWT-BS3579-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to the N-terminal of Human Cofilin 1.
• Konjugation: Unconjugated
• Alternative Synonym: Cofilin-1, 18 kDa phosphoprotein, p18, Cofilin, non-muscle isoform, CFL1, CFL

Produktbeschreibung

Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally-associated Actin subunits, changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK-1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F-Actin.

Produkteigenschaften

• Molekulargewicht: ~ 19 kDa
• UniProt: P23528
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Anwendungsbeschreibung

• Application Verdünnung: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
• Anwendungsbeschreibung: Cofilin (M1) polyclonal antibody detects endogenous levels of Cofilin protein.