Synthetic peptide, corresponding to amino acids 108-157 of Human Septin 2.
Konjugation:
Unconjugated
Alternative Synonym:
DIFF6, hNEDD5, KIAA0158, Neural precursor cell expressed developmentally down regulated protein 5, Pnutl3, Protein NEDD5, SEPT2
The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. At least three septins (Septin 1, 2 and 4) are associated with a Tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Septin 3 (G-Septin), a GTPbinding protein, is highly expressed in brain and is regulated by protein kinase G in neurons. The human SEPT4 (H5/PNUTL2/CDCrREL-2) gene encodes ARTS (for apoptosis-related protein in the TGF beta signaling pathway), which is expressed in many cells and acts to enhance cell death induced by TGF beta or, to a lesser extent, by other apoptotic agents. ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
