Synthetic peptide, corresponding to amino acids 250-300 of Human OATP1.
Konjugation:
Unconjugated
Alternative Synonym:
Solute carrier organic anion transporter family member 1A2, OATP-A, Organic anion-transporting polypeptide 1, OATP-1, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, SLCO1A2, OATP, OATP1, OATP1A2, SLC21A3
The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:200
Anwendungsbeschreibung:
OATP1 (N286) polyclonal antibody detects endogenous levels of OATP1 protein.
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