AKT1, AKT1, AKT2, AKT3, MGC9965, Oncogene AKT1, PKB alpha, PKB, PKB beta, PKBalpha, PRKBA, PRKBB, PRKBG, Protein kinase B, Protein kinase B beta, Protein kinase B gamma, Proto-oncogene c-Akt, RAC alpha, RAC, RAC gamma, RAC PK alpha, RAC PK beta, RAC
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH) domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold, overexpression or inappropriate activation of AKT has been seen in many types of cancer.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:200
Anwendungsbeschreibung:
p-Akt (S473) polyclonal antibody detects endogenous levels of p-Akt protein only when phosphorylated at Ser473.
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