AR (phospho-S650) polyclonal antibody, Unconjugated, Rabbit
Artikelnummer:
BWT-BS4012
Hersteller Artikelnummer:
BS4012
Alternativnummer:
BWT-BS4012-50UL,BWT-BS4012-100UL
Hersteller:
Bioworld Technology
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human, Rat
Immunogen:
Synthetic phosphopeptide derived from human AR around the phosphorylation site of Serine 650.
Konjugation:
Unconjugated
Alternative Synonym:
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about 3 times more rapid than those of DHT. This difference in binding kinetics may account for the different physiological effects of T and DHT. Androgen binding results in an at least 6-fold increase in androgen receptor stability.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
IHC: 1:50~1:200
Anwendungsbeschreibung:
p-AR (S650) polyclonal antibody detects endogenous levels of Androgen Receptor protein only when phosphorylated at Ser650 .
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
