Cyclic AMP-dependent transcription factor ATF-4, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67,
ATF4, an activating transcription factor/cAMP-response element-binding protein family member, functions in the PERK and eIF2alpha ER stress responsive pathway. ER stress represses the translation of the majority of mRNAs, but selectively stimulates the translation of certain mRNAs including that of ATF-4. Induced expression of ATF-4 increases the expression of genes critical for the recovery from ER stress.
