CANDF7, ISGF 3, Signal transducer and activator of transcription 1, Stat1, STAT91, Transcription factor ISGF-3 components p91/p84,
The Stat1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-alpha and IFN-gamma. Stat1 protein exists as a pair of isoforms, Stat1alpha (91 kDa) and the splice variant Stat1beta (84 kDa). In most cells, both isoforms are activated by IFN-alpha, but only Stat1alpha is activated by IFN-gamma. The inappropriate activation of Stat1 occurs in many tumors.
