Ash and phospholipase C gamma-binding protein, NAP4, Nck, Nck Ash and phospholipase C binding protein, Nck associated protein 4, NCKAP4, SH2 domain containing SOCS box protein, SOCS4, SOCS6, Socs7, Suppressor of cytokine signaling 7,
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.
