RUNX1 (phospho-S249) polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: RUNX1 (phospho-S249) polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS4211
• Hersteller Artikelnummer: BS4211
• Alternativnummer: BWT-BS4211-50UL,BWT-BS4211-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Serine 249.
• Konjugation: Unconjugated
• Alternative Synonym: Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, RUNX1, AML1, CBFA2

Produktbeschreibung

AML1 (also known as Runx1, CBFA2, and PEBP2alphaB) is a member of the core binding factor (CBF) family of transcription factors. It is required for normal development of all hematopoietic lineages. AML1 forms a heterodimeric DNA binding complex with its partner protein CBFbeta and regulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8,21) AML1-ETO, t(12,21) TEL-AML, and t(8,21) AML-M2. Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner.

Produkteigenschaften

• Molekulargewicht: ~ 55 kDa
• UniProt: Q01196
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Anwendungsbeschreibung

• Application Verdünnung: WB: 1:500~1:1000
• Anwendungsbeschreibung: RUNX1 (phospho-S249) polyclonal antibody detects endogenous levels of RUNX1 protein only when phosphorylated at Ser249.