Synthetic phosphopeptide derived from human Cytokeratin 8 around the phosphorylation site of Serine 432
Konjugation:
Unconjugated
Alternative Synonym:
Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, Type-II keratin Kb8, KRT8, CYK8
CK2 (formerly called Casein Kinase II) is a highly conserved protein kinase with more than 300 substrates regulating cell growth, cell death, and cell survival. CK2 has been implicated in the response to UV irradiation-induced DNA damage, targeting XRCC1 and BRCA1 as well as regulating p53 tumor suppressor protein functions.Furthermore, CK2 plays a key role in NF-kappaB activation.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000
Anwendungsbeschreibung:
Casein Kinase IIbeta (phospho-S209) polyclonal antibody detects endogenous levels of Casein Kinase IIbeta protein only when phosphorylated at Ser209.
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