Enables apolipoprotein binding activity, lipoprotein particle binding activity, and low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to insulin stimulus, cellular response to starvation, and regulation of neuron apoptotic process. Acts upstream of or within several processes, including low-density lipoprotein receptor particle metabolic process, regulation of low-density lipoprotein particle receptor catabolic process, and triglyceride metabolic process. Located in COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum, and extracellular space. Is expressed in several structures, including alimentary system, cerebellum, genitourinary system, liver, and telencephalon. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Apr 2022]
Store at -20C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
