PFKFB2 (phospho-S483) polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: PFKFB2 (phospho-S483) polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS4859
• Hersteller Artikelnummer: BS4859
• Alternativnummer: BWT-BS4859-50UL,BWT-BS4859-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthetic phosphopeptide derived from human PFKFB2 around the phosphorylation site of Serine 483.
• Konjugation: Unconjugated
• Alternative Synonym: PFK-2 car, PFK-2 cardiac, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, 6PF-2-K/Fru-2,6-P2ase 2, PFK/FBPase 2, 6PF-2-K/Fru-2,6-P2ase heart-type isozyme, 6-phosphofructo-2-kinase, Fructose-2,6-bisphosphatase, PFKFB2

Produktbeschreibung

PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose-2,6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regulator for PFK-1. PFK-2 catalyzes the synthesis of fructose-2,6-bisphosphate, and contains fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).

Produkteigenschaften

• Molekulargewicht: ~ 58 kDa
• UniProt: O60825
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Anwendungsbeschreibung

• Application Verdünnung: WB: 1:500~1:1000 IHC: 1:50~1:200
• Anwendungsbeschreibung: p-PFKFB2 (S483) polyclonal antibody detects endogenous levels of PFKFB2 protein only when phosphorylated at Ser483.