CYP2J2 (cytochrome P450 2J2), also known as CPJ2, is a member of the cytochrome P450 protein superfamily. Localized to the ER (endoplasmic reticulum) and microsomal membranes, CYP2J2 is one of three cytochrome P450 enzymes that are responsible for metabolizing arachidonic acid to epoxyeicosatrienoic acids. Functioning via an NADPH-dependent olefin epoxidation, CYP2J2 epoxidizes endogenous cardiac arachidonic acid pools to four different isoforms of epoxyeicosatrienoic acid, all of which are important regulators of cardiovascular homeostasis and vascular tone. CYP2J2 is highly expressed in the heart with low levels of expression found in the liver, colon and kidneys. Up-regulation of CYP2J2 by a c-Jun responsive pathway is thought to promote the neoplastic phenotype of certain carcinoma cells, implicating CYP2J2 in carcinogenesis.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200
Anwendungsbeschreibung:
CYP2J2 polyclonal antibody detects endogenous levels of CYP2J2 protein.
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