A synthetic peptide corresponding to residues in Human HLA-DQB1/B2
Konjugation:
Unconjugated
Alternative Synonym:
HLA class II histocompatibility antigen, DQ beta 1 chain, MHC class II antigen DQB1, HLA-DQB1, HLA-DQB, HLA class II histocompatibility antigen, DQ beta 2 chain, HLA class II histocompatibility antigen, DX beta chain, MHC class II antigen DQB2, HLA-DQB2, HLA-DXB
Destination of major histocompatibility complex (MHC) class II molecules for presentation to CD4+ helper T-cells is determined by two key events: the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, DQ, DP and DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. The alpha 1 chain of HLA-DQ1 class II molecule complex can bind peptides and present them to CD4+ T lymphocytes. HLA-DQB1 may be implicated in multiple sclerosis.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000
Anwendungsbeschreibung:
HLA-DQB1/B2 polyclonal antibody detects endogenous levels of HLA-DQB1/B2 protein.
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