Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. CPD (carboxypeptidase D), also known as GP180 or metallocarboxypeptidase D, is a 1,380 amino acid single-pass type I membrane protein that belongs to the peptidase M14 family. CPD binds two zinc ions per subunit and contains three carboxypeptidase-like domains. CPD causes the release of C-terminal arganine and lysine from polypeptides. Highest expression of CPD is found in pancreas, hepatoma cells and placenta, with lower levels in heart, skeletal muscle and colon carcinoma. Mammalian CPD is a homolog of the duck hepatitis B virus-binding protein gp180.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000
Anwendungsbeschreibung:
CABIN1 polyclonal antibody detects endogenous levels of CABIN1 protein.
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