Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. The Synaptotagmin family of proteins share a common domain structure that consists of a transmembrane domain and a cytoplasmic region composed of two C2 domains. Synaptotagmin VIII, also known as SYT8, is a 401 amino acid single-pass type III membrane protein belonging to the Synaptotagmin family. Containing two C2 domains, Synaptotagmin VIII exists as a homodimer or homooligomer. Synaptotagmin VIII exists as two alternatively spliced isoforms, isoform 1 and isoform 4. Synaptotagmin VIII isoform 4 is thought to participate in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:204
Anwendungsbeschreibung:
SYT8 polyclonal antibody detects endogenous levels of SYT8 protein.
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