A synthetic peptide corresponding to residues in Human ADAM28.
Konjugation:
Unconjugated
Alternative Synonym:
Disintegrin and metalloproteinase domain-containing protein 28, ADAM 28, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, eMDC II, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, MDC-L, ADAM28, ADAM23, MDCL
The ADAM (a disintegrin and metalloprotease) protein family, which includes over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases, plays a role in cell-cell and cell-matrix interface related processes, including fertilization, muscle fusion, secretion of TNFalpha (tumor necrosis factor alpha), and modulation of the neurogenic function of Notch and Delta. The ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand), a cysteine-rich region, an epidermal growth factorlike domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in a wide range of mammalian tissues and several are abundantly expressed in the male reproductive tract. ADAM28, also designated MDC-L,is more closely related to snake venom metalloproteases (SVMPs) than to other ADAM family members. ADAM28 displays a high level of expression in lymphocytes and epididymis, and functions mainly on the cell surface, where it mediates cell adhesion through its binding to integrin alpha4beta1. The gene encoding human ADAM28 maps to chromosome 8p21.2.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000 IHC: 1:50~1:200
Anwendungsbeschreibung:
ADAM28 polyclonal antibody detects endogenous levels of ADAM28 protein.
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