MYLIP polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: MYLIP polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS61709
• Hersteller Artikelnummer: BS61709
• Alternativnummer: BWT-BS61709-50UL,BWT-BS61709-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids 150-200 of Human MYLIP.
• Konjugation: Unconjugated
• Alternative Synonym: E3 ubiquitin-protein ligase MYLIP, Inducible degrader of the LDL-receptor, Idol, Myosin regulatory light chain interacting protein, MIR, RING-type E3 ubiquitin transferase MYLIP, MYLIP, BZF1, IDOL, BM-023, PP5242

Produktbeschreibung

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Produkteigenschaften

• Molekulargewicht: ~ 49 kDa
• UniProt: Q8WY64
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Anwendungsbeschreibung

• Application Verdünnung: WB: 1:500~1:1000
• Anwendungsbeschreibung: MYLIP polyclonal antibody detects endogenous levels of MYLIP protein.