Mannose Binding Protein polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: Mannose Binding Protein polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS62399
• Hersteller Artikelnummer: BS62399
• Alternativnummer: BWT-BS62399-50UL,BWT-BS62399-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to Human Mannose Binding Protein.
• Konjugation: Unconjugated
• Alternative Synonym: COLEC 1, COLEC1, Collectin-1, HSMBPC, Mannan binding lectin, Mannan binding protein, Mannan-binding protein, Mannose binding lectin (protein C) 2 soluble, Mannose binding lectin (protein C) 2, soluble (opsonic defect), Mannose binding lectin (protein C) 2, soluble, Mannose binding lectin 2 soluble, Mannose binding lectin 2, soluble (opsonic defect), Mannose binding lectin, Mannose binding lectin protein C2 soluble opsonic defect, Mannose binding protein, Mannose binding protein C, Mannose binding protein C precursor, Mannose-binding lectin, Mannose-binding protein C, MBL 2, MBL, MBL2, MBL2_HUMAN, MBL2D, MBP 1, MBP, MBP C, MBP-C, MBP1, MBPB, MBPC, MGC116832, MGC116833, Opsonic defect, protein C, Soluble mannose binding lectin

Produktbeschreibung

Mannose-binding lectin protein C (MBL-C), also known as mannose-binding protein C, mannose-binding lectin 2, soluble (opsonic defect), mannan-binding lectin, mannan-binding protein, and soluble mannose-binding lectin, initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL-C is a key component in immune response due to its ability to directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2+-dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, two types of MBL-associated serine proteases (MASP-1 and MASP-2) and a truncated form of MASP-2, designated small MBL-associated protein (sMAP) or MAp19, complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.

Produkteigenschaften

• Molekulargewicht: ~ 26 kDa
• UniProt: P11226
• Reinheit: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Anwendungsbeschreibung

• Application Verdünnung: WB:1:500~1:1000
• Anwendungsbeschreibung: Mannose Binding Protein polyclonal antibody detects endogenous levels of Mannose Binding protein.