Protein phosphatase 1K, mitochondrial, PP2C domain-containing protein phosphatase 1K, PP2C-like mitochondrial protein, PP2C-type mitochondrial phosphoprotein phosphatase, PTMP, Protein phosphatase 2C isoform kappa, PP2C-kappa, PPM1K, PP2CM
PP2Ckappa (protein phosphatase 2C isoform kappa), also known as PP2C-type mitochondrial phosphoprotein phosphatase and PP2C domain-containing protein phosphatase 1K, is a 372 amino acid mitochondrial matrix protein that regulates the opening of mitochondrial membrane permeability transition pores. PP2Ckappa is essential for cell survival, cardiac function and embryonic development. Knockdown of PP2Ckappa results in cell death due to loss of mitochondrial membrane potential. PP2Ckappa specifically binds to the branched-chain-alphaketoacid dehydrogenase (BCKD) complex and induces dephosphorylation of Ser293, effectively leading to the inhibition of branched chain amino acid metabolism. Highest expression of PP2Ckappa is found in brain, diaphragm and heart. There are three isoforms of PP2Ckappa that are produced as a result of alternative splicing events.
