Synthetic Acetylated peptide derived from human TAL1 around the Acetylation site of K221/K222.
Konjugation:
Unconjugated
Alternative Synonym:
T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5, TAL1,T-cell acute lymphocytic leukemia protein 2, TAL-2, Class A basic helix-loop-helix protein 19, bHLHa19, TAL2
Activation of TAL1 characterizes up to 60% ofcases of human T cell acute lymph oblastic leukemia,making it themost frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helixtranscription factorknown to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box.In addition, leukemogenesisis accelerated dramatically bytransgenic coexpression of TAL1 and the catalyticsubunit ofcasein kinase IIalpha, a serine/threonine protein kinase known tomodulate the activity of other betaHLH transcription factors.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:1000
Anwendungsbeschreibung:
TAL1 (Acetyl-K221/K222) polyclonal antibody detects endogenous levels of TAL1 protein only when acetylated at Lys221 and Lys222. This antibody also recognizes TAL2 protein when acetylated at Lys36 and Lys37.
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