CASP9 (phospho-S144) polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: CASP9 (phospho-S144) polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS64250
• Hersteller Artikelnummer: BS64250
• Alternativnummer: BWT-BS64250-50UL,BWT-BS64250-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic phosphopeptide derived from human CASP9 around the phosphorylation site of Serine 144.
• Konjugation: Unconjugated
• Alternative Synonym: Caspase-9, CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6, Caspase-9 subunit p35, Caspase-9 subunit p10, CASP9, MCH6

Produktbeschreibung

Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf-1. Apaf-1 mediated activation of caspase-9 involves intrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis.

Produkteigenschaften

• Molekulargewicht: ~ 47 kDa
• UniProt: P55211
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Anwendungsbeschreibung

• Application Verdünnung: WB: 1:500~1:1000
• Anwendungsbeschreibung: CASP9(Phospho-S144) polyclonal antibody detects endogenous levels of CASP9 protein only when phosphorylated at Ser144.