Synthetic phosphopeptide derived from human Ataxin 1 around the phosphorylation site of Serine 775.
Konjugation:
Unconjugated
Alternative Synonym:
alternative ataxin1, Ataxin-1, ATX1, ATX1_HUMAN, Atxn1, D6S504E, SCA1, Spinocerebellar ataxia type 1 protein
Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200
Anwendungsbeschreibung:
Ataxin 1 (Phospho-S775) polyclonal antibody detects endogenous levels of Ataxin 1 protein only when phosphorylated at Ser775.
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