Histone H4 (Phospho-S47) polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: Histone H4 (Phospho-S47) polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS64530
• Hersteller Artikelnummer: BS64530
• Alternativnummer: BWT-BS64530-50UL,BWT-BS64530-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, WB
• Spezies Reaktivität: Human, Rat
• Immunogen: Synthetic phosphopeptide derived from human Histone H4 around the phosphorylation site of Serine 47.
• Konjugation: Unconjugated
• Alternative Synonym: Histone H4, HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4

Produktbeschreibung

Histone proteins H3, H4, H2A, and H2B function as building blocks to package eukaryotic DNA into repeating nucleosome units that are folded in higher order chromatin fibers. The nucleosome is composed of an octamer containing a H3/H4 tetramer and two H2A/H2B dimers, surrounded by approximately 146 base pairs of DNA. A diverse and elaborate array of post-translational modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occurs on the N-terminal tail domains of histones. Methylation of position-specific lysine residues in histone N termini is a central modification for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist in a mono, di, or tri methylated state. Arginine resdiues can also by mono or di methylated.

Produkteigenschaften

• Molekulargewicht: ~ 11 kDa
• UniProt: P62805
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Anwendungsbeschreibung

• Application Verdünnung: WB:1:500~1:1000 IF:1:50~1:200
• Anwendungsbeschreibung: Histone H4 (Phospho-S47) polyclonal antibody detects endogenous levels of Histone H4 protein only when phosphorylated at Ser47.