Synthetic phosphopeptide derived from human hnRNP D0 around the phosphorylation site of Serine 83.
Konjugation:
Unconjugated
Alternative Synonym:
Heterogeneous nuclear ribonucleoprotein D0, hnRNP D0, AU-rich element RNA-binding protein 1, AUF1, HNRPD, HNRNPD
hnRNP D/AUF1 binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3 untranslated regions of many protooncogenes and cytokine mRNAs. It also binds to double and single stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single stranded nonmonotonous 5-UUAG-3 sequence and also weaker to the single-stranded 5-TTAGGG-3 telomeric DNA repeat. It may be involved in translationally coupled mRNA turnover (referenced from swissprot).
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200
Anwendungsbeschreibung:
hnRNP D0 (Phospho-S83) polyclonal antibody detects endogenous levels of hnRNP D0 protein only when phosphorylated at Ser83.
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