Canine, Equine, Human, Mouse, Porcine, Rabbit, Rat
Immunogen:
KLH conjugated synthetic peptide derived from human NKIRAS1:131-192/192
Konjugation:
Unconjugated
Alternative Synonym:
2400004O09Rik, I kappa B interacting Ras like protein 1, I-kappa-B-interacting Ras-like protein 1, Kappa B Ras 1, Kappa B Ras protein 1, Kappa B-Ras protein 1, KappaB Ras1, KappaB-Ras1, KBRAS 1, KBRAS1, KBRS1_HUMAN, NF kappa B inhibitor interacting Ras like protein 1, NF-kappa-B inhibitor-interacting Ras-like protein 1, NFKB inhibitor interacting Ras like 1, NFKB inhibitor interacting Ras like protein 1, NKIRAS 1, nkiras1.
Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. IkappaBinteracting Ras-like proteins, kappaB-Ras1 and kappaB-Ras2, belong to a subclass of evolutionarily conserved Ras-like proteins that differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These Ras-like proteins, kappaB-Ras1 and kappaB-Ras2, interact with the PEST domains of IkappaBa and IkappaBb and decrease their rate of degradation. kappaB-Ras2 shows 71% identity to kappaB-Ras1. In cells,kappaB-Ras proteins are associated only with NFkappaB:IkappaBb complexes and therefore may provide an explanation for the slower rate of degradation of IkappaBb compared with IkappaBa.
