BLM polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: BLM polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS65549
• Hersteller Artikelnummer: BS65549
• Alternativnummer: BWT-BS65549-50UL,BWT-BS65549-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC-P
• Spezies Reaktivität: Equine, Human, Mouse, Porcine, Rabbit, Rat
• Immunogen: KLH conjugated synthetic peptide derived from human BLM:761-860/1417
• Konjugation: Unconjugated
• Alternative Synonym: Blooms Syndrome Protein Blm, BLM, BLM_HUMAN, Bloom Syndrome, Bloom syndrome protein, Bloom syndrome RecQ helicase like, BS, DNA Helicase, DNA helicase RecQ like type 2, MGC126616, MGC131618, MGC131620, RECQ 2, RECQ like, RecQ like type 2, RecQ protein like 3, RecQ Protein-like 3, RECQ-2, RECQ-Like, RecQ-like type 2, RECQ2, RECQL 2, RECQL 3, RECQL-2, RECQL-3, RECQL2, RECQL3, type 2.

Produktbeschreibung

Blooms syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Blooms syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Blooms syndrome patients. One characteristic of Blooms syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Blooms cells.

Produkteigenschaften

• Molekulargewicht: ~159kDa
• UniProt: P54132
• Reinheit: affinity purified by Protein A
• Formulierung: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Anwendungsbeschreibung

• Application Verdünnung: IHC-P=1:100-500 () not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
• Anwendungsbeschreibung: BLM polyclonal Antibody detects endogenous levels of BLM protein.