TNFSF14 polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: TNFSF14 polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS65551
• Hersteller Artikelnummer: BS65551
• Alternativnummer: BWT-BS65551-50UL,BWT-BS65551-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Mouse
• Immunogen: KLH conjugated synthetic peptide derived from mouse TNFSF14:59-130/239
• Konjugation: Unconjugated
• Alternative Synonym: CD 258, CD258, CD258 antigen, Delta transmembrane LIGHT, Herpes virus entry mediator ligand, Herpesvirus entry mediator A, Herpesvirus entry mediator ligand, herpesvirus entry mediator-ligand, HVEM L, HVEM-L, HVEML, Ligand for herpesvirus entry mediator, LIGHT, LTg, soluble form, TNF14, TNF14_HUMAN, TNFSF 14, TNFSF14 protein, TR 2, TR2, Tumor necrosis factor (ligand) superfamily, member 14, Tumor necrosis factor ligand superfamily member 14, Tumor necrosis factor ligand superfamily, member 14, Tumor necrosis factor receptor like 2, tumor necrosis factor receptor-like 2, Tumor necrosis factor superfamily member 14, Tumor necrosis factor superfamily member LIGHT.

Produktbeschreibung

LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as death domain. LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

Produkteigenschaften

• Molekulargewicht: ~26kDa
• UniProt: Q9QYH9
• Reinheit: affinity purified by Protein A
• Formulierung: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Anwendungsbeschreibung

• Application Verdünnung: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
• Anwendungsbeschreibung: TNFSF14 polyclonal Antibody detects endogenous levels of TNFSF14 protein.